Independent product guide

NSK Prophy-Mate neo, Perio-Mate & Varios Combi Pro2

Last reviewed: October 20, 2026 · DentalAirPolisher Editorial Team

NSK (Nakanishi Inc., Japan) covers air polishing with two handpieces and one combined tabletop system. What each does, which powders it takes and what it costs.

Quick answer

NSK's air-polishing range has three parts. The Prophy-Mate neo is an air-polishing handpiece with 60° and 80° nozzles and fully autoclavable components. The Perio-Mate is its subgingival sibling for periodontal and peri-implant work. The Varios Combi Pro2 is a combined tabletop system (piezo ultrasonic plus air polishing) launched at IDS 2025.

NSK's Flash Pearl powder is calcium carbonate (~54 µm), not sodium bicarbonate.

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Prophy-Mate neo (handpiece)

CategoryAir-polishing handpiece on the dental-unit coupling (not a tabletop system)
Made inJapan
Nozzles60° and 80°, selected manually for access
ReprocessingFully autoclavable (all components)
CouplingsMultiple compatible options — confirm your unit's coupling before ordering
PowdersNSK Flash Pearl (calcium carbonate, ~54 µm); glycine
PricePrice on request

Perio-Mate (subgingival)

The Perio-Mate is NSK's subgingival air-polishing handpiece, intended for subgingival biofilm management and peri-implant maintenance. It uses NSK's PERIO-MATE powder, a glycine powder with particles under 25 µm. It is available within the Varios Combi Pro2 set-up or separately; a standalone price is not consistently published.

Varios Combi Pro2 (combined tabletop system)

CategoryCombined tabletop system (ultrasonic scaling + air polishing)
LaunchIDS 2025; successor to the Varios Combi Pro
UltrasonicPiezoelectric, 28–32 kHz; pure-titanium ultrasonic handpiece (NSK describes it as a world first), designed for repeated reprocessing and autoclaving
Weight3.5 kg (irrigation bottle and chamber not included) (NSK)
Ultrasonic output11 W maximum
Foot controlWireless foot control
PowdersFLASH pearl (calcium carbonate, 54 µm); SOFT pearl (glycine, 65 µm); Perio Mate Powder (glycine, 25 µm)
PricePrice on request

NSK uses the label MIT for its branded protocol.

Powders: what to know

More detail in our powder comparison.

Alternatives to compare

FDA and Health Canada records (U.S. and Canada)

FDA 510(k) K112673 (Prophy-Mate neo, Nakanishi, Inc., decision date February 7, 2012, class I). We found no Health Canada licence for the neo. For the Varios Combi Pro2: FDA 510(k) K260773 (decision date March 10, 2026) and Health Canada licence 115743. For the Perio-Mate: confirm with supplier. A 510(k) decision means "substantially equivalent" to a predicate; it is not FDA approval. A missing record means we could not verify it, not that the device cannot be sold. Confirm with the supplier that the record covers the exact model and kit. Records queried October 16, 2026. Source: openFDA 510(k) database and Health Canada MDALL.

Frequently asked questions

Is NSK Flash Pearl sodium bicarbonate?

No. Flash Pearl is a calcium carbonate powder with particles of about 54 µm. It is for supragingival use only.

What is the difference between the Prophy-Mate neo and the Perio-Mate?

The Prophy-Mate neo is NSK's general air-polishing handpiece (60° and 80° nozzles, Flash Pearl or glycine). The Perio-Mate is for subgingival and peri-implant work and uses PERIO-MATE glycine powder (under 25 µm).

What is the NSK Varios Combi Pro2?

A combined tabletop system launched at IDS 2025 that pairs a 28–32 kHz piezo ultrasonic scaler (with a pure-titanium handpiece) and air polishing. NSK lists a unit weight of 3.5 kg (without irrigation bottle and chamber) and a wireless foot control.

References

  1. Francis S, Caponio VCA, Spirito F, Perrotti V, Quaranta A. Microbiological and Physical Changes Produced by Different Air-Powders on Contaminated Titanium Implant Surfaces: An In Vitro Pilot Study. Applied Sciences. 2023;13:1301. doi:10.3390/app13031301

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DentalAirPolisher.com is independent in its editorial content. We may receive compensation from suppliers when a quote request leads to a sale; this never changes what we write.